Lymphangiogenesis in development and disease.
Identifieur interne : 007222 ( Main/Exploration ); précédent : 007221; suivant : 007223Lymphangiogenesis in development and disease.
Auteurs : Taija M Kinen [Allemagne] ; Kari Alitalo [Finlande]Source :
- Novartis Foundation symposium [ 1528-2511 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
- cytologie : Cellules endothéliales.
- embryologie : Vaisseaux lymphatiques, Vaisseaux sanguins.
- Animaux, Différenciation cellulaire, Lymphangiogenèse, Maladie, Souris.
English descriptors
- KwdEn :
- MESH :
- cytology : Endothelial Cells.
- embryology : Blood Vessels, Lymphatic Vessels.
- Animals, Cell Differentiation, Disease, Lymphangiogenesis, Mice.
Abstract
Lymphatic vessels are important for the maintenance of normal tissue fluid balance, for immune surveillance and adsorption of digested fats. In spite of their important functions in physiological as well as in various pathological conditions, including tumour metastasis, lymphoedema and inflammation, the lymphatic vessels have not received as much attention as the blood vessels, and the mechanisms regulating their development and growth have been poorly understood. However, recent studies using mouse genetic tools and primary lymphatic endothelial cell cultures have greatly increased our understanding of how the lymphatic endothelial cells differentiate, how lymphatic vessel growth is regulated and how the remodelling of the lymphatic vasculature into a functional vessel network consisting of capillaries and collecting vessels occurs. Furthermore, these studies have also provided mechanistic insights into the processes involved in pathological lymphangiogenesis.
PubMed: 18300416
Affiliations:
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Le document en format XML
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xml:lang="fr"><term>Animaux</term><term>Cellules endothéliales (cytologie)</term><term>Différenciation cellulaire</term><term>Lymphangiogenèse</term><term>Maladie</term><term>Souris</term><term>Vaisseaux lymphatiques (embryologie)</term><term>Vaisseaux sanguins (embryologie)</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules endothéliales</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term><term>Vaisseaux sanguins</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Blood Vessels</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Differentiation</term><term>Disease</term><term>Lymphangiogenesis</term><term>Mice</term></keywords><keywords scheme="MESH" 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In spite of their important functions in physiological as well as in various pathological conditions, including tumour metastasis, lymphoedema and inflammation, the lymphatic vessels have not received as much attention as the blood vessels, and the mechanisms regulating their development and growth have been poorly understood. However, recent studies using mouse genetic tools and primary lymphatic endothelial cell cultures have greatly increased our understanding of how the lymphatic endothelial cells differentiate, how lymphatic vessel growth is regulated and how the remodelling of the lymphatic vasculature into a functional vessel network consisting of capillaries and collecting vessels occurs. Furthermore, these studies have also provided mechanistic insights into the processes involved in pathological lymphangiogenesis.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Finlande</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name></noRegion></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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